Important Factors When Staining Zirconia Ceramic

09/05/2023

Important Factors When Staining Zirconia Ceramic

In this blog post, I will share with you some important factors that affect the final color of zirconia ceramic restorations. As a professional dental ceramist, I know how challenging it can be to achieve a natural and harmonious shade match with zirconia ceramic. Zirconia ceramic is a strong and biocompatible material that can be used for various types of dental restorations, such as crowns, bridges, and implants. However, zirconia ceramic has some limitations when it comes to aesthetics, such as low translucency and high opacity. Therefore, staining zirconia ceramic is a crucial step to enhance its appearance and mimic the natural tooth color.

100417

Staining zirconia ceramic involves applying different shades of stains to the surface of the restoration to create depth, characterization, and chroma. However, staining zirconia ceramic is not a simple task. It requires careful planning and consideration of various factors that influence the final color of the restoration. These factors include:

The dental substrate: This is the natural tooth structure or implant abutment that supports the restoration. The dental substrate can affect the final color of the restoration by reflecting or absorbing light. For example, a dark dental substrate can make the restoration appear darker or more grayish than intended. Therefore, it is important to select a suitable shade of zirconia coping that can mask the dental substrate and provide a neutral base for the veneering ceramic and glaze.

100411

The cement: This is the material that bonds the restoration to the dental substrate. The cement can also affect the final color of the restoration by altering its translucency and value. For example, light-colored cement can increase the translucency and brightness of the restoration, while dark-colored cement can decrease them. Therefore, it is important to select a compatible shade of cement that matches the desired color of the restoration and does not interfere with its optical properties.

100413

The zirconia coping: This is the core or framework of the restoration that provides strength and support. The zirconia coping can affect the final color of the restoration by influencing its thickness and opacity. For example, a thin zirconia coping can increase the translucency and chroma of the restoration, while a thick zirconia coping can decrease them. Therefore, it is important to fabricate zirconia coping with an optimal thickness that balances strength and esthetics.

The veneering ceramic: This is the layer of ceramic that covers the zirconia coping and creates the shape and contour of the restoration. The veneering ceramic can affect the final color of the restoration by determining its hue and saturation. For example, a warm veneering ceramic can create a yellowish or reddish hue, while a cool veneering ceramic can create a bluish or grayish hue. Therefore, it is important to choose a suitable shade of veneering ceramic that matches the natural tooth color and blends with the adjacent teeth.

100415

The glaze: This is the final layer of ceramic that seals the surface of the restoration and adds gloss and smoothness. The glaze can affect the final color of the restoration by modifying its value and characterization. For example, a clear glaze can increase the value and brightness of the restoration, while a colored glaze can add stains and effects to enhance its realism. Therefore, it is important to apply an appropriate amount and type of glaze that complements the underlying layers and creates a natural appearance.

The laboratory procedure: This is the process of fabricating and finishing the restoration in the dental laboratory. The laboratory procedure can affect the final color of the restoration by influencing its accuracy and quality. For example, improper handling, firing, or polishing of the restoration can cause defects or distortions that alter its color or surface texture. Therefore, it is important to follow a standardized and precise laboratory procedure that ensures consistency and reliability of the restorations.

As you can see, staining zirconia ceramic is not as simple as applying some colors to a white surface. It requires careful consideration of multiple factors that interact with each other and affect the final color of the restoration. By understanding these factors and their effects, you can improve your skills and confidence in staining zirconia ceramics and achieve more predictable and satisfactory results for your patients.

References:

1. Ingole VH, Sathe B, Ghule AV. Bioactive ceramic composite material stability, characterization. In: Fundamental Biomaterials: Ceramics. Duxford: Woodhead Publishing. (2018). p. 273–96. doi: 10.1016/B978-0-08-102203-0.00012-3

CrossRef Full Text | Google Scholar

2. Ram S, Singh G P. Advanced ZrO 2-Based ceramic nanocomposites for optical and other engineering applications. In: Composite Materials. Berlin: Springer (2017). p. 497–570. doi: 10.1007/978-3-662-49514-8_15

CrossRef Full Text | Google Scholar

3. Ghasemi-Kahrizsangi S, Karamian E, Gheisari Dehsheikh H, Ghasemi-Kahrizsangi A. A review on recent advances on magnesia-doloma refractories by nano-technology. J Water Environ Nanotechnol. (2017) 2:206–22. doi: 10.22090/jwent.2017.03.008

CrossRef Full Text | Google Scholar

4. Sun T, Liu G, Ou L, Feng X, Chen A, Lai R, et al. Toxicity induced by zirconia oxide nanoparticles on various organs after intravenous administration in rats. J Biomed Nanotechnol. (2019) 15:728–41. doi: 10.1166/jbn.2019.2717

PubMed Abstract | CrossRef Full Text | Google Scholar

5. Wang J, Stevens R. Surface toughening of TZP ceramics by low temperature ageing. Ceram Int. (1989) 15:15–21. doi: 10.1016/0272-8842(89)90004-7

CrossRef Full Text | Google Scholar

6. Meyenberg KH, Lüthy H, Schärer P. Zirconia posts: a new all-ceramic concept for nonvital abutment teeth. J Esthet Dent. (1995) 7:73–80. doi: 10.1111/j.1708-8240.1995.tb00565.x

PubMed Abstract | CrossRef Full Text | Google Scholar

7. Camposilvan E, Leone R, Gremillard L, Sorrentino R, Zarone F, Ferrari M, et al. Aging resistance mechanical properties and translucency of different yttria-stabilized zirconia ceramics for monolithic dental crown applications. Dent Mater. (2018) 34:879–90. doi: 10.1016/j.dental.2018.03.006

PubMed Abstract | CrossRef Full Text | Google Scholar

8. Priyadarshini B, Rama M, Chetan, Vijayalakshmi U. Bioactive coating as a surface modification technique for biocompatible metallic implants: a review. J Asian Ceram Soc. (2019) 7:397–406. doi: 10.1080/21870764.2019.1669861

PubMed Abstract | CrossRef Full Text | Google Scholar

9. Hanawa T. Zirconia versus titanium in dentistry: a review. Dental Mater J. (2020) 39:24–36. doi: 10.4012/dmj.2019-172

PubMed Abstract | CrossRef Full Text | Google Scholar

10. Grech J, Antunes E. Zirconia in dental prosthetics: a literature review. J Mater Res Technol. (2019) 8:4956–64. doi: 10.1016/j.jmrt.2019.06.043

CrossRef Full Text | Google Scholar

11. Chen YW, Moussi J, Drury JL, Wataha JC. Zirconia in biomedical applications. Exp Rev Med Dev. (2016) 13:945–63. doi: 10.1080/17434440.2016.1230017

CrossRef Full Text | Google Scholar

12. Huang Q, Elkhooly TA, Liu X, Zhang R, Yang X, Shen Z, et al. Effects of hierarchical micro/ nano-topographies on the morphology, proliferation and differentiation of osteoblast-like cells. Colloids Surf B Biointerfaces. (2016) 145:37–45. doi: 10.1016/j.colsurfb.2016.04.031

PubMed Abstract | CrossRef Full Text | Google Scholar

13. Liu Y, Rath B, Tingart M, Eschweiler J. Role of implants surface modification in osseointegration: a systematic review. J Biomed Mater Res Part A. (2020) 108:470–84. doi: 10.1002/jbm.a.36829

PubMed Abstract | CrossRef Full Text | Google Scholar

14. Zafar MS, Fareed MA, Riaz S, Latif M, Habib SR, Khurshid Z. Customized therapeutic surface coatings for dental implants. Coatings. (2020) 10:568. doi: 10.3390/coatings10060568

CrossRef Full Text | Google Scholar

15. Bosshardt DD, Chappuis V, Buser D. Osseointegration of titanium, titanium alloy and zirconia dental implants: current knowledge and open questions. Periodontology. (2017) 73:22–40. doi: 10.1111/prd.12179

PubMed Abstract | CrossRef Full Text | Google Scholar

16. Mishra S, Chowdhary R. PEEK materials as an alternative to titanium in dental implants: a systematic review. Clin Implant Dent Relat Res. (2019) 21:208–22. doi: 10.1111/cid.12706

PubMed Abstract | CrossRef Full Text | Google Scholar

17. Brunello G, Brun P, Gardin C, Ferroni L, Bressan E, Meneghello R, et al. Biocompatibility and antibacterial properties of zirconium nitride coating on titanium abutments: an in vitro study. PLoS ONE. (2018) 13:e0199591. doi: 10.1371/journal.pone.0199591

PubMed Abstract | CrossRef Full Text | Google Scholar

18. Pulgarin HLC, Albano MP. Sintering, microstrusture and hardness of different alumina–zirconia composites. Ceram Int. (2014) 40:5289–98. doi: 10.1016/j.ceramint.2013.10.102

PubMed Abstract | CrossRef Full Text | Google Scholar

19. Zhou M, Liu W, Wu H, Song X, Chen Y, Cheng L. Preparation of a defect-free alumina cutting tool via additive manufacturing based on stereolithography–Optimization of the drying and debinding processes. Ceram Int. (2016) 42:11598–602. doi: 10.1016/j.ceramint.2016.04.050

CrossRef Full Text | Google Scholar

20. Kalyoncuoglu UT, Yilmaz B, Koc SG, Evis Z, Arpaci PU, Kansu G. Investigation of surface structure and biocompatibility of chitosan-coated zirconia and alumina dental abutments. Clin Implant Dent Relat Res. (2018) 20:1022–9. doi: 10.1111/cid.12665

PubMed Abstract | CrossRef Full Text | Google Scholar

21. Deng QX, Ou YS, Zhu Y, Zhao ZH, Liu B, Huang Q. Clinical outcomes of two types of cages used in transforaminal lumbar interbody fusion for the treatment of degenerative lumbar diseases: n-HA/PA66 cages versus PEEK cages. J Mater Sci Mater Med. (2016) 27:102. doi: 10.1007/s10856-016-5712-7

PubMed Abstract | CrossRef Full Text | Google Scholar

22. Yuan Y, Liu C, Huang M. The structure and performance of short glass fiber/high-density polyethylene/polypropylene composite pipes extruded using a shearing(-) drawing compound stress field. Materials. (2019) 12:1323. doi: 10.3390/ma12081323

PubMed Abstract | CrossRef Full Text | Google Scholar

23. Guertler A, Thomas P, Herzinger T. [Pseudo allergic reaction to metal implant]. Hautarzt. (2018) 69:14–5. doi: 10.1007/s00105-018-4184-8

PubMed Abstract | CrossRef Full Text | Google Scholar

24. Zhao W, He B, Zhou A, Li Y, Chen X, Yang Q. D-RADA16-RGDreinforced nano-hydroxyapatite/polyamide 66 ternary biomaterial for bone formation. Tissue Eng Regen Med. (2019) 16:177–89. doi: 10.1007/s13770-018-0171-5

PubMed Abstract | CrossRef Full Text | Google Scholar

25. Qu Y, Wang P, Man Y, Li Y, Zuo Y, Li J. Preliminary biocompatible evaluation of nano-hydroxyapatite/polyamide 66 composite porous membrane. Int J Nanomed. (2010) 5:429–35. doi: 10.2147/IJN.S10710

PubMed Abstract | CrossRef Full Text | Google Scholar

26. Sharifi F, Atyabi SM, Norouzian D, Zandi M, Irani S, Bakhshi H. Polycaprolactone/carboxymethyl chitosan nanofibrous scaffolds for bone tissue engineering application. Int J Biol Macromol. (2018) 115:243–8. doi: 10.1016/j.ijbiomac.2018.04.045

PubMed Abstract | CrossRef Full Text | Google Scholar

27. Soult MD, Lien W, Savett DA, Gallardo FF, Vandewalle KS. Effect of high-speed sintering on the properties of a zirconia material. Gen Dent. (2019) 67:30–4.

PubMed Abstract | Google Scholar

28. de Oliveira GR, Pozzer L, Cavalieri-Pereira L, de Moraes PH, Olate S, de Albergaría Barbosa JR. Retraction: bacterial adhesion and colonization differences between zirconia and titanium implant abutments: an in vivo human study. J Periodontal Implant Sci. (2019) 49:58. doi: 10.5051/jpis.2019.49.1.58

PubMed Abstract | CrossRef Full Text | Google Scholar

29. Jungmann R, Szabo ME, Schitter G, Tang RYS, Vashishth D, Hansma PK, et al. Local strain, and damage mapping in single trabeculae during three point bending tests. J Mech Behav Biomed Mater. (2011) 4:523–34. doi: 10.1016/j.jmbbm.2010.12.009

PubMed Abstract | CrossRef Full Text | Google Scholar

30. Li J, Zuo Y, Cheng X, Yang W, Wang H, Li Y. Preparation and characterization of nano-hydroxyapatite/polyamide 66 composite GBR membrane with asymmetric porous structure. J Mater Sci Mater Med. (2009) 20:1031–8. doi: 10.1007/s10856-008-3664-2

PubMed Abstract | CrossRef Full Text | Google Scholar

31. Lu M, Liao J, Dong J, Wu J, Qiu H, Zhou X. An effective treatment of experimental osteomyelitis using the antimicrobial titanium/silver-containing nHP66 (nano-hydroxyapatite/polyamide-66) nanoscaffold biomaterials. Sci Rep. (2016) 6:39174. doi: 10.1038/srep39174

PubMed Abstract | CrossRef Full Text | Google Scholar

32. Ardila MAN, Costa HL, de Mello JDB. Influence of the ball material on friction and wear in microabrasion tests. Wear. (2020) 450:203266. doi: 10.1016/j.wear.2020.203266

CrossRef Full Text | Google Scholar

33. Teles VC, de Mello JDB, da Silva WM Jr. Abrasive wear of multilayered/gradient CrAlSiN PVD coatings: Effect of interface roughness and of superficial flaws. Wear. (2017) 376:1691–701. doi: 10.1016/j.wear.2017.01.116

CrossRef Full Text | Google Scholar

34. Bajraktarova-Valjakova E, Korunoska-Stevkovska V, Kapusevska B, Gigovski N, Bajraktarova-Misevska C, Grozdanov A. Contemporary dental ceramic materials, a review: chemical composition, physical and mechanical properties, indications for use. Open Access Maced J Med Sci. (2018) 6:1742–55. doi: 10.3889/oamjms.2018.378

PubMed Abstract | CrossRef Full Text | Google Scholar

35. Piconi C, Condo SG, Kosmač T. Alumina-and zirconia-based ceramics for load-bearing applications. Adv Ceram Dent. (2014) 219–53. doi: 10.1016/B978-0-12-394619-5.00011-0

CrossRef Full Text | Google Scholar

36. Aloise JP, Curcio R, Laporta MZ, Rossi L, da Silva AM, Rapoport A. Microbial leakage through the implant abutment interface of morse taper implant in vitroClin Oral Implants Res. (2010) 21:328–35. doi: 10.1111/j.1600-0501.2009.01837.x

PubMed Abstract | CrossRef Full Text | Google Scholar

37. do Nascimento C, Barbosa RE, Issa JP, Watanabe E, Ito IY, Albuquerque RF Jr. Bacterial leakage along the implant abutment interface of premachined or cast components. Int J Oral Maxillofac Surg. (2008) 37:177–80. doi: 10.1016/j.ijom.2007.07.026

PubMed Abstract | CrossRef Full Text | Google Scholar

38. Hermann JS, Schoolfield JD, Schenk RK, Buser D, Cochran DL. Influence of the size of microgap on crestal bone changes around titanium implants. A histometric evaluation of unloaded non-submerged implants in the canine mandible. J Periodontol. (2001) 72:1372–83. doi: 10.1902/jop.2001.72.10.1372

PubMed Abstract | CrossRef Full Text | Google Scholar

39. Harder S, Dimaczek B, Acil Y, Terheyden H, Freitag-Wolf S, Kern M. Molecular leakage at implant-abutment connection in vitro investigation of tightness of internal conical implant-abutment connections against endotoxin penetration. Clin Oral Investig. (2009) 14:427–32. doi: 10.1007/s00784-009-0317-x

PubMed Abstract | CrossRef Full Text | Google Scholar

40. Broggini N, McManus LM, Hermann JS, Medina R, Schenk RK, Buser D, et al. Peri-implant inflammation defined by the implant-abutment interface. J Dent Res. (2006) 85:473–8. doi: 10.1177/154405910608500515

PubMed Abstract | CrossRef Full Text | Google Scholar

41. Prakasam M, Locs J, Salma-Ancane K, Loca D, Largeteau A, Berzina-Cimdina L. Biodegradable materials and metallic implants-a review. J Funct Biomater. (2017) 8:44. doi: 10.3390/jfb8040044

PubMed Abstract | CrossRef Full Text | Google Scholar

42. Großner-Schreiber B, Teichmann J, Hannig M, Dorferv C, Wenderoth D, Ott S. Modified implant surfaces show different biofilm composition under in vivo conditions. Clin Oral Implants Res. (2009) 20:817–26. doi: 10.1111/j.1600-0501.2009.01729.x

PubMed Abstract | CrossRef Full Text | Google Scholar

43. Rasouli R, Barhoum A, Uludag H. A review of nanostructured surfaces and materials for dental implants: surface coating, patterning and functionalization for improved performance. Biomater Sci. (2018) 6:1312–38. doi: 10.1039/C8BM00021B

PubMed Abstract | CrossRef Full Text | Google Scholar

44. Zhang K, Van Le Q. Bioactive glass coated zirconia for dental implants: a review. J Compos Compounds. (2020) 2:10–7. doi: 10.29252/jcc.2.1.2

CrossRef Full Text | Google Scholar

45. Chang HI, Wang Y. Cell responses to surface and architecture of tissue engineering scaffolds. In: Regenerative Medicine and Tissue Engineering-Cells and Biomaterials. InTechOpen (2011). doi: 10.5772/21983

PubMed Abstract | CrossRef Full Text | Google Scholar

46. Wakabayashi H, Yamauchi K, Kobayashi T, Yaeshima T, Iwatsuki K, Yoshie H. Inhibitory effects of lactoferrin on growth and biofilm formation of Porphyromonas gingivalis and Prevotella intermediaAntimicrobial Agents Chemother. (2009) 53:3308–16. doi: 10.1128/AAC.01688-08

PubMed Abstract | CrossRef Full Text | Google Scholar

47. Lima EMCX, Koo H, Vacca-Smith AM, Rosalen PL, Del Bel Cury AA. Adsorption of salivary and serumproteins, and bacterial adherence on titanium and zirconia ceramic surfaces. Clin Oral Implants Res. (2008) 19:780–5. doi: 10.1111/j.1600-0501.2008.01524.x

CrossRef Full Text | Google Scholar

48. Sardin S, Morrier J, Benay G, Barsotti O. In vitro streptococcal adherence on prosthetic and implant materials. Interactions with physicochemical surface properties. J Oral Rehabil. (2004) 31:140–8. doi: 10.1046/j.0305-182X.2003.01136.x

PubMed Abstract | CrossRef Full Text | Google Scholar

49. Nikam A, Pagar T, Ghotekar S, Pagar K, Pansambal S. A review on plant extract mediated green synthesis of zirconia nanoparticles and their miscellaneous applications. J Chem Rev. (2019) 1:154–63. doi: 10.33945/SAMI/JCR.2019.3.1

CrossRef Full Text | Google Scholar

50. Ostroushko AA, Grzhegorzhevskii KV, Medvedeva SYE, Gette IF, Tonkushina MO, Gagarin IYD, et al. Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use. Nanosyst Phys Chem Mathe. (2021) 12:81–112. doi: 10.17586/2220-8054-2021-12-1-81-112

CrossRef Full Text | Google Scholar

51. Fakhardo AF, Anastasova EI, Gabdullina SR, Solovyeva AS, Saparova VB, Chrishtop VV. Toxicity patterns of clinically relevant metal oxide nanoparticles. ACS Appl Bio Mater. (2019) 2:4427–35. doi: 10.1021/acsabm.9b00615

CrossRef Full Text | Google Scholar

52. Degidi M, Artese L, Scarano A, Perrotti V, Gehrke P, Piattelli A. Inflammatory infiltrate microvessel density, nitric oxide synthase expression, vascular endothelial growth factor expression, and proliferative activity in peri-implant soft tissues around titanium and zirconium oxide healing caps. J Periodontol. (2006) 77:73–80. doi: 10.1902/jop.2006.77.1.73

PubMed Abstract | CrossRef Full Text | Google Scholar

53. El-Bassyouni GT, Eshak MG, Barakat IAH, Khalil WKB. Immunotoxicity evaluation of novel bioactive composites in male mice as promising orthopaedic implants. Cent Euro J Immunol. (2017) 42:54. doi: 10.5114/ceji.2017.67318

PubMed Abstract | CrossRef Full Text | Google Scholar

54. Dobrzański LA, Dobrzańska-Danikiewicz AD, Achtelik-Franczak A, Dobrzański LB, Hajduczek E, Matula G. Fabrication technologies of the sintered materials including materials for medical and dental application. In: Powder Metallurgy–Fundamentals and Case Studies. Rijeka: InTech (2017). p. 17–52. doi: 10.5772/65376

CrossRef Full Text | Google Scholar

55. Sennerby L, Dasmah A, Larsson B, Iverhed M. Bone tissue responses to surface-modified zirconia implants: a histomorphometric and removal torque study in the rabbit. Clin Implant Dent Relat Res. (2005) 7:S13–20. doi: 10.1111/j.1708-8208.2005.tb00070.x

PubMed Abstract | CrossRef Full Text | Google Scholar

56. Viswanathan V, Laha T, Balani K, Agarwal A, Seal S. Challenges and advances in nanocomposite processing techniques. Mater Sci Eng R Rep. (2006) 54:121–85. doi: 10.1016/j.mser.2006.11.002

CrossRef Full Text | Google Scholar

57. Glauser R, Sailer I, Wohlwend A, Studer S, Schibli M, Schärer P. Experimental zirconia abutments for implant-supported single-tooth restorations in aesthetically demanding regions: 4-year results of a prospective clinical study. Int J Prosthodont. (2004) 17:285–90.

Google Scholar

58. Tschernitschek H, Borchers L, Geurtsen W. Nonalloyed titanium as a bioinert metal: a review. Quintessence Int. (2005) 36:523–30.

PubMed Abstract | Google Scholar

59. Macan J, Sikirić MD, Deluca M, Bermejo R, Baudin C, Plodinec M. Mechanical properties of zirconia ceramics biomimetically coated with calcium deficient hydroxyapatite. J Mech Behav Biomed Mater. (2020) 111:104006. doi: 10.1016/j.jmbbm.2020.104006

PubMed Abstract | CrossRef Full Text | Google Scholar

60. Quan R, Yang D, Wu X, Wang H, Miao X, Li W. In vitro and in vivo biocompatibility of graded hydroxyapatite-zirconia composite bioceramic. J Mater Sci Mater Med. (2008) 19:183–7. doi: 10.1007/s10856-006-0025-x

PubMed Abstract | CrossRef Full Text | Google Scholar

61. Wu H, Liu W, He R, Wu Z, Jiang Q, Song X. Fabrication of dense zirconia-toughened alumina ceramics through a stereolithography-based additive manufacturing. Ceramics International. (2017) 43:968–72. doi: 10.1016/j.ceramint.2016.10.027

CrossRef Full Text | Google Scholar

62. Felgueiras HP, Migonney V. Cell spreading morphology variations as a result of protein adsorption bioactive coating on Ti6Al4V surfaces. IRBM. (2016) 37:165–71. doi: 10.1016/j.irbm.2016.03.006

CrossRef Full Text | Google Scholar

63. Fraioli R, Dashnyam K, Kim JH, Perez RA, Kim HW, Gil J. Surface guidance of stem cell behavior: chemically tailored co-presentation of integrin-binding peptides stimulates osteogenic differentiation in vitro and bone formation in vivoActa Biomater. (2016) 43:269–81. doi: 10.1016/j.actbio.2016.07.049

PubMed Abstract | CrossRef Full Text | Google Scholar

64. Huang Q, Liu X, Elkhooly TA, Zhang R, Shen Z, Feng Q. A novel titania/calcium silicate hydrate hierarchical coating on titanium. Colloids Surf B Biointerfaces. (2015) 134:169–77. doi: 10.1016/j.colsurfb.2015.07.002

PubMed Abstract | CrossRef Full Text | Google Scholar

65. Ho GW, Matinlinna JP. Insights on ceramics as dental materials. Part I: ceramic material types in dentistry. Silicon. (2011) 3:109–15. doi: 10.1007/s12633-011-9078-7

CrossRef Full Text | Google Scholar

66. Costa AMM. Development of Bioactive Materials for Dental Implants Using Powder Metallurgy. Portugal: Master thesis (2016).

PubMed Abstract | Google Scholar

67. Zhuang LF, Jiang HH, Qiao SC, Appert C, Si MS, Gu YX, et al. The roles of extracellular signalregulated kinase 1/2 pathway in regulating osteogenic differentiation of murine preosteoblasts MC3T3-E1 cells on roughened titanium surfaces. J Biomed Mater Res A. (2012) 100:125–33. doi: 10.1002/jbm.a.33247

CrossRef Full Text | Google Scholar

68. Galli C, Passeri G, Ravanetti F, Elezi E, Pedrazzoni M, Macaluso GM. Rough surface topography enhances the activation of Wnt/beta-catenin signaling in mesenchymal cells. J Biomed Mater Res A. (2010) 95:682–90. doi: 10.1002/jbm.a.32887

PubMed Abstract | CrossRef Full Text | Google Scholar

69. Feng B, Weng J, Yang BC, Qu SX, Zhang XD. Characterization of surface oxide films on titanium and adhesion of osteoblast. Biomaterials. (2003) 24:4663–70. doi: 10.1016/S0142-9612(03)00366-1

PubMed Abstract | CrossRef Full Text | Google Scholar

70. Chani MTS, Khan SB, Asiri AM, Karimov KS, Rub MA. Photo-thermoelectric cells based on pristine α-Al2O3 co-doped CdO, CNTs and their single and bi-layer composites with silicone adhesive. J Taiwan Inst Chem Eng. (2015) 52:93–9. doi: 10.1016/j.jtice.2015.02.005

CrossRef Full Text | Google Scholar

71. Gittens RA, McLachlan T, Olivares-Navarrete R, Cai Y, Berner S, Tannenbaum R. The effects of combined micron-/submicron-scale surface roughness and nanoscale features on cell proliferation and differentiation. Biomaterials. (2011) 32:3395–403. doi: 10.1016/j.biomaterials.2011.01.029

PubMed Abstract | CrossRef Full Text | Google Scholar

72. Zhao Sh, Seitz J-M. Eifler R, Maier HJ, Guillory II RJ, Earley EJ, et al. Zn-Li alloy after extrusion and drawing: Structural, mechanical characterization, and biodegradation in abdominal aorta of rat. Mater Sci Eng C Mater Biol Appl. (2017) 76::301–12. doi: 10.1016/j.msec.2017.02.167

CrossRef Full Text | Google Scholar

73. Satish P, Satuluri S, Sivarao S. Recent Advances in Material Sciences. In Satish P, editor. Select Proceedings of ICLIET. Berlin: Springer (2108). p. 771–72.

Google Scholar

74. Kawashima N, Soetanto K, Watanabe K, Ono K, Matsuno T. The surface characteristics of the sintered body of hydroxyapatite zirconia composite particles. Colloids Surf B Bioint. (1997) 10:23–27. doi: 10.1016/S0927-7765(97)00041-6

CrossRef Full Text | Google Scholar

75. Salem NA, Abo TA, Aboushelib MN. Biomechanical and histomorphometric evaluation of osseointegration of fusion-sputtered zirconia implants. J Prosthodont. (2013) 22:261–7. doi: 10.1111/j.1532-849X.2012.00940.x

PubMed Abstract | CrossRef Full Text | Google Scholar

76. Aboushelib MN, Salem NA, Taleb AL, El MN. Influence of surface nano-roughness on osseointegration of zirconia implants in rabbit femur heads using selective infiltration etching technique. J Oral Implantol. (2013) 39:583–90. doi: 10.1563/AAID-JOI-D-11-00075

PubMed Abstract | CrossRef Full Text | Google Scholar

77. Wennerberg A, Albrektsson T. Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Implants Res. (2009) 20(Suppl. 4):172–84. doi: 10.1111/j.1600-0501.2009.01775.x

PubMed Abstract | CrossRef Full Text | Google Scholar

78. Conserva E, Lanuti A, Menini M. Cell behavior related to implant surfaces with different microstructure and chemical composition: an in vitro analysis. Int J Oral Maxillofac Implants. (2010) 25:1099–107.

PubMed Abstract | Google Scholar

79. Conserva E, Menini M, Ravera G, Pera P. The role of surface implant treatments on the biological behavior of SaOS-2 osteoblast-like cells. An in vitro comparative study. Clin Oral Implants Res. (2013) 24:880–9. doi: 10.1111/j.1600-0501.2011.02397.x

PubMed Abstract | CrossRef Full Text | Google Scholar

80. Le Guehennec L, Soueidan A, Layrolle P, Amouriq Y. Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater. (2007) 23:844–54. doi: 10.1016/j.dental.2006.06.025

PubMed Abstract | CrossRef Full Text | Google Scholar

81. Baldi D, Menini M, Pera F, Ravera G, Pera P. Plaque accumulation on exposed titanium surfaces and peri-implant tissue behavior. A preliminary 1-year clinical study. Int J Prosthodont. (2009) 22:447–55.

PubMed Abstract | Google Scholar

82. Sanon C, Chevalier J, Douillard T, Kohal RJ, Coelho PG, Hjerppe J, et al. Low temperature degradation and reliability of one-piece ceramic oral implants with a porous surface. Dent Mater. (2013) 29:389–97. doi: 10.1016/j.dental.2013.01.007

PubMed Abstract | CrossRef Full Text | Google Scholar

83. Frigan K, Chevalier J, Zhang F, Spies BC. Is a zirconia dental implant safe when it is available on the market? Ceramics. (2019) 2:568–77. doi: 10.3390/ceramics2040044

CrossRef Full Text | Google Scholar