Designing and fabricating a well-functioning, aesthetic, and durable denture requires the dentist to consider factors from multiple aspects, including patient demands, oral anatomy, material selection, etc. Developing an individualized design plan is the key step to success.

The most fundamental consideration is the patient's aesthetic and functional demands. Is a high simulation of natural contours needed? Are high masticatory forces expected? What about speech clarity? These needs will inform design decisions. An elderly patient may only require basic chewing capacity, while a younger patient will desire high aesthetics.

Next, making full use of existing oral structures is very important. If teeth roots remain, their utilization to increase support and retention must be considered. The design should avoid depressed tissue areas and adequately cover hard tissues. Assessing to generate proper vertical dimension is also necessary.

Choice of denture materials also impacts outcomes. Acrylic resin looks more natural but is brittle and prone to fracture. Traditional polymethyl methacrylate is more wear-resistant but less aesthetic. Metal bases are stronger and suitable for patients with severe bone loss. Materials should match patient needs.

The technician must also consider various clinical parameters like centric relation, anterior guidance, buccal corridor fullness, tissue finish line design, etc., all affecting aesthetics and function. Leveraging digital techniques like scanning and CAD software can enable precise design.

Fabricating multiple try-ins, modifying and adjusting is critical to ensure design success. This necessitates multiple dentist-patient interactions to reach optimal outcomes. Only by considering all relevant variables and actively integrating patient feedback, can patient satisfaction be enhanced.